Murphy, M.A., Sungkwang, M., Horstemyer, M., Baskes, M., Bakhtiarydavijani, A., Laplaca, M.C., Gwaltney, S., Williams, L.N., Prabhu, R. Molecular dynamics simulations showing 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) membrane mechanoporation damage under different strain paths, Journal of Biomolecular Structure & Dynamics. 2018, DOI: 10.1080/07391102.2018.1453376
[DOI]Rush, G. Alston, Prabhu, R., Rush, Gus A. III, Williams, L.N., Horstemeyer, M.F., “A Modified Drop Test for American Football Helmets,” Journal of Visualized Experiments, 2017, DOI:10.3791/53929 2017.
[DOI]Prabhu, R., Whittington, Wilburn., Jones, Michael David, Darwall, Dan, Liao, Jun, Williams, L.N. Dynamic compressive mechanical properties of the porcine immature brain. Brain Injury. 30, 2016:674
Murphy, M.A., Horstemeyer, M.F., Gwaltney, S., Stone, T., Laplaca, Michelle, Liao, J., Williams, L.N., Prabhu, R. Nanomechanics of phospholipid bilayer failure under strip biaxial stretching using molecular dynamics. Modelling and Simulation in Materials Science and Engineering. 24, 2016: 055008
Begonia, M.T., Prabhu, R., Liao, J., Whittington, W.R., Claude, A., Willeford, B., Wardlaw, J., Wu, R., Zhang, S., Williams, L.N. Quantitative Analysis of Brain Microstructure Following Blunt and Blast Trauma, Journal of Biomechanics. 47, 2014: 3704-3711.
[PDF]Prabhu, R., Horstemeyer, M., Marin, E., Bouvard, J-L., Tucker, M., Sherburn, J., Liao, J., Williams, L.N., Coupled Experiment / Finite Element Analysis on the Mechanical Response of Porcine Brain under High Strain Rates, Journal of Mechanical Behavior of Biological Materials. 4(7), 2011: 1067-1080 doi:10.1016/j.jmbbm.2011.03.015, 2011
[PDF]Begonia, M., Liao, J., Horstemeyer, M., Williams, L.N., Structure-Property Relations of Porcine Brain Tissue: Strain Rate and Stress-State Dependence, Annals of Biomedical Engineering. 38(10), 2010:3043-57
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TM3 is investigating the deformation behavior of native cranial soft tissues to lay a scientific foundation for designing superior tissue surrogates with optimized properties, and developing a tissue engineered dura mater patch with the objective of preventing problems associated with synthetic patches which include CSF leakage and patch integration with the native tissue.
TM3 is developing a constitutive model of the anterior cruciate ligament in an effort to model mechanistic changes that cannot be captured experimentally.
Alexander Knapp and Lakiesha N. Williams, Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, 2022, 9, https://doi.org/10.3390/ bioengineering9020054
Mark T. Begonia, Alexander M. Knapp, R.K. Prabhu, Jun Liao, and Lakiesha N. Williams, Shear-deformation based continuum-damage constitutive modeling of brain tissue, Journal of Biomechanics. 2021, 117; doi.org/10.1016/j.jbiomech.2021.110260
Bryn L. Brazile, J. Ryan Butler, Sourav S. Patnaik, Andrew Claude, Raj Prabhu, Lakiesha N. Williams, Karla L. Perez, Kytai T. Nguyen, Ge Zhang, Pietro Bajona, Matthias Peltz , Yong Yang c, Yi Hong , Jun Liao Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction, Journal of Mechanical Behavior of Biomedical Materials. 2021, 116, doi.org/10.1016/j.jmbbm.2021.104342
R. K. Prabhu, M. T. Begonia, W. R. Whittington, M. A. Murphy, Y. Mao, J. Liao, L. N. Williams , M. F. Horstemeyer, J. Sheng. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects, Bioengineering. 2019, 6(2), 40; doi:10.3390/bioengineering6020040
[DOI]Joseph Chen, Sourav S. Patnaik, R. K. Prabhu, Lauren B. Priddy, Jean-Luc Bouvard1, Esteban Marin, M. F. Horstemeyer, Jun Liao, and Lakiesha N. Williams. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression, Bioengineering. 2019, 6(2), 49; doi:10.3390/bioengineering6020049
[DOI]Chen, J., Bryn, B. Prabhu, R., Patnaik, S.S., Bertucci, R., Rhee, H., Horstemeyer, M.F., Hong, Y., Williams, L. N., Liao, J. Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear, Journal of Biomechanical Engineering. 2018, DOI: 10.1115/1.4039825.
[PDF] [DOI]Prabhu, R., Kovach, A. D., Nguyen, V., Gambino, J., Zachary, F., Bulla, S., Liao, J., Williams, L. N. Prospective preliminary in vitro investigation of a magnetic iron oxide nanoparticle conjugated with ligand CD80 and VEGF antibody as a targeted drug delivery system for the induction of cell death in rodent osteosarcoma cells. Bioresearch Open Access.5, 2016:299-307
Prabhu, R., Horstemeyer, M., Mao, M., Whittington, W., Patnaik, S., Begonia, M., Williams, L.N., Liao, J. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials, Journal of Visualized Experiments. 2015
Li, F., Yang, J., Liao, Jiali, Li, S., Liao, Jun, Prabhu, R., Williams, L.N., Tang, Y., Tang, J., Liu, N. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 276, 2015:322-330
Weed, B., Patnaik, S., Rougeau-Browning, M., Brazile, B., Liao, J., Prabhu, R., Williams, L.N. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 8, 2015:2454-2466
Wheatley, B. B., Pietsch, R. B., Donahue, T.L.H., Williams, L.N. Fully non-linear hyper-viscoelastic modeling of skeletal muscle in compression. Computer Methods in Biomechanics and Biomedical Engineering. 2015: DOI:10.1080/10255842.2015.1118468
[DOI]Brazile, B., B. Wang, G. Wang, R. Bertucci, R. Prabhu, S.S. Patnaik, J.R. Butler, A.K. Claude, E. Brinkman-Ferguson, L.N. Williams, and J. Liao. On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants 25 2015:1-14.
Pietsch, R., Wheatley, B.B., Donahue, T.L.H., Gilbrech, R., Prabhu, R., Liao, J., Williams, L.N. Anisotropic Compressive Properties of Passive Porcine Muscle Tissue, Journal of Biomechanical Engineering. 136 (11), 2014: DOI: 10.1115/1.4028088
[DOI]Bo Wang, Guangjun Wang, Filip To, J. Ryan Butler, Andrew Claude, Ronald M. McLaughlin, L. N. Williams, Amy L. de Jongh Curry, and Jun Liao. Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations. Langmuir 29, 2013: 11109-11117
Weed B.C., Borazjani, A., Patnaik, S.S., Prabhu, R., Horstemeyer, M.F., Ryan, P.L., Franz, T., Williams, L. N., Liao, J. Stress State and Strain Rate Dependence of the Human Placenta, Annals of Biomedical Engineering. 40(10), 2012: 2255-65.
Wang, B., Tedder, M.E., Perez, C.E., Wang, G., Curry, A.L., To, F., Elder, S. H., Williams, L. N., Simionescu, D. T., Liao, J. Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix, Journal of Materials Science: Materials in Medicine. 23(8), 2012: 1835-1847
[PDF]Bertucci, R., Gilbrech, R., Mao, M., Prabhu, R., Horstemeyer, M.F., Liao, J., Williams, L.N. Development of a Lower Extremity Model at Blast Conditions HFM-207, NATO Symposium on Blast Injury. No. 17, 2011.
Liao, J., Joyce, E.M., Merryman, D.W., Jones, H.L., Tahai, M., Horstemeyer, M.F., Williams, L.N., Hopkins, R.A., Sacks, M.S. The Intrinsic Fatigue Mechanism of the Porcine Aortic Valve Extracellular Matrix, Cardiovascular Engineering and Technology. 3(1), 2012: 62-72
[PDF]Clemmer, J., Liao, J., Davis, D., Horstemeyer, M., Williams, L.N., A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon, Journal of Biomechanics. 43, 2010: 2785-2791.
[PDF]Subramanian, S., Elder, S. H., Horstemeyer, M.F., Williams, L.N. Experimental Investigation of Anisotropic Shear Properties of Rabbit Patellar Tendon, Biological Engineering. 1, 2008: 255-264.
[PDF]Williams, L.N., Elder, S. H., Bouvard, J.L., Horstemeyer, M.F., The Anisotropic Compressive Mechanical Properties of the Rabbit Patellar Tendon, Biorheology. 45, 2008:577-586.
[PDF]Williams, L.N., Elder, S.H., Harbarger, D., Horstemeyer, M.F., Variation of diameter distribution, number density, and area fraction of fibrils within five areas of the Rabbit Patellar Tendon, Annals of Anatomy. 190, 2008: 442-451.
[PDF]Claude, L.N., Solomonow, M., Zhou, B., Baratta R.V., Zhu, M. Neuromuscular Disorder Elicited by Cyclic Lumbar Flexion. Muscle and Nerve 27, 2003: 348-358.
Alexander Knapp and Lakiesha N. Williams, Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, 2022, 9, https://doi.org/10.3390/ bioengineering9020054
Mark T. Begonia, Alexander M. Knapp, R.K. Prabhu, Jun Liao, and Lakiesha N. Williams, Shear-deformation based continuum-damage constitutive modeling of brain tissue, Journal of Biomechanics. 2021, 117; doi.org/10.1016/j.jbiomech.2021.110260
Bryn L. Brazile, J. Ryan Butler, Sourav S. Patnaik, Andrew Claude, Raj Prabhu, Lakiesha N. Williams, Karla L. Perez, Kytai T. Nguyen, Ge Zhang, Pietro Bajona, Matthias Peltz , Yong Yang c, Yi Hong , Jun Liao Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction, Journal of Mechanical Behavior of Biomedical Materials. 2021, 116, doi.org/10.1016/j.jmbbm.2021.104342
R. K. Prabhu, M. T. Begonia, W. R. Whittington, M. A. Murphy, Y. Mao, J. Liao, L. N. Williams , M. F. Horstemeyer, J. Sheng. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects, Bioengineering. 2019, 6(2), 40; doi:10.3390/bioengineering6020040
[DOI]Joseph Chen, Sourav S. Patnaik, R. K. Prabhu, Lauren B. Priddy, Jean-Luc Bouvard1, Esteban Marin, M. F. Horstemeyer, Jun Liao, and Lakiesha N. Williams. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression, Bioengineering. 2019, 6(2), 49; doi:10.3390/bioengineering6020049
[DOI]Chen, J., Bryn, B. Prabhu, R., Patnaik, S.S., Bertucci, R., Rhee, H., Horstemeyer, M.F., Hong, Y., Williams, L. N., Liao, J. Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear, Journal of Biomechanical Engineering. 2018, DOI: 10.1115/1.4039825.
[PDF] [DOI]Prabhu, R., Kovach, A. D., Nguyen, V., Gambino, J., Zachary, F., Bulla, S., Liao, J., Williams, L. N. Prospective preliminary in vitro investigation of a magnetic iron oxide nanoparticle conjugated with ligand CD80 and VEGF antibody as a targeted drug delivery system for the induction of cell death in rodent osteosarcoma cells. Bioresearch Open Access.5, 2016:299-307
Prabhu, R., Horstemeyer, M., Mao, M., Whittington, W., Patnaik, S., Begonia, M., Williams, L.N., Liao, J. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials, Journal of Visualized Experiments. 2015
Li, F., Yang, J., Liao, Jiali, Li, S., Liao, Jun, Prabhu, R., Williams, L.N., Tang, Y., Tang, J., Liu, N. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 276, 2015:322-330
Weed, B., Patnaik, S., Rougeau-Browning, M., Brazile, B., Liao, J., Prabhu, R., Williams, L.N. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 8, 2015:2454-2466
Wheatley, B. B., Pietsch, R. B., Donahue, T.L.H., Williams, L.N. Fully non-linear hyper-viscoelastic modeling of skeletal muscle in compression. Computer Methods in Biomechanics and Biomedical Engineering. 2015: DOI:10.1080/10255842.2015.1118468
[DOI]Brazile, B., B. Wang, G. Wang, R. Bertucci, R. Prabhu, S.S. Patnaik, J.R. Butler, A.K. Claude, E. Brinkman-Ferguson, L.N. Williams, and J. Liao. On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants 25 2015:1-14.
Pietsch, R., Wheatley, B.B., Donahue, T.L.H., Gilbrech, R., Prabhu, R., Liao, J., Williams, L.N. Anisotropic Compressive Properties of Passive Porcine Muscle Tissue, Journal of Biomechanical Engineering. 136 (11), 2014: DOI: 10.1115/1.4028088
[DOI]Bo Wang, Guangjun Wang, Filip To, J. Ryan Butler, Andrew Claude, Ronald M. McLaughlin, L. N. Williams, Amy L. de Jongh Curry, and Jun Liao. Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations. Langmuir 29, 2013: 11109-11117
Weed B.C., Borazjani, A., Patnaik, S.S., Prabhu, R., Horstemeyer, M.F., Ryan, P.L., Franz, T., Williams, L. N., Liao, J. Stress State and Strain Rate Dependence of the Human Placenta, Annals of Biomedical Engineering. 40(10), 2012: 2255-65.
Wang, B., Tedder, M.E., Perez, C.E., Wang, G., Curry, A.L., To, F., Elder, S. H., Williams, L. N., Simionescu, D. T., Liao, J. Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix, Journal of Materials Science: Materials in Medicine. 23(8), 2012: 1835-1847
[PDF]Bertucci, R., Gilbrech, R., Mao, M., Prabhu, R., Horstemeyer, M.F., Liao, J., Williams, L.N. Development of a Lower Extremity Model at Blast Conditions HFM-207, NATO Symposium on Blast Injury. No. 17, 2011.
Liao, J., Joyce, E.M., Merryman, D.W., Jones, H.L., Tahai, M., Horstemeyer, M.F., Williams, L.N., Hopkins, R.A., Sacks, M.S. The Intrinsic Fatigue Mechanism of the Porcine Aortic Valve Extracellular Matrix, Cardiovascular Engineering and Technology. 3(1), 2012: 62-72
[PDF]Clemmer, J., Liao, J., Davis, D., Horstemeyer, M., Williams, L.N., A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon, Journal of Biomechanics. 43, 2010: 2785-2791.
[PDF]Subramanian, S., Elder, S. H., Horstemeyer, M.F., Williams, L.N. Experimental Investigation of Anisotropic Shear Properties of Rabbit Patellar Tendon, Biological Engineering. 1, 2008: 255-264.
[PDF]Williams, L.N., Elder, S. H., Bouvard, J.L., Horstemeyer, M.F., The Anisotropic Compressive Mechanical Properties of the Rabbit Patellar Tendon, Biorheology. 45, 2008:577-586.
[PDF]Williams, L.N., Elder, S.H., Harbarger, D., Horstemeyer, M.F., Variation of diameter distribution, number density, and area fraction of fibrils within five areas of the Rabbit Patellar Tendon, Annals of Anatomy. 190, 2008: 442-451.
[PDF]Claude, L.N., Solomonow, M., Zhou, B., Baratta R.V., Zhu, M. Neuromuscular Disorder Elicited by Cyclic Lumbar Flexion. Muscle and Nerve 27, 2003: 348-358.
TM3 lab generates 3D reconstructions of tissues and organs from CT and MR images. Finite element models of these reconstructions are created to predict injury to the tissues and organs while subjected to various conditions.
TM3 lab is working on designing impact mitigating materials inspired from natural systems. We are using lessons from nature to optimize designs of protective gear for soldiers and athletes.
Alexander Knapp and Lakiesha N. Williams, Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, 2022, 9, https://doi.org/10.3390/ bioengineering9020054
L. Johnson, M.W. Trim, Y. Mao, H. Rhee, L. N. Williams, J. Liao, J. Griggs, M.F. Horstemeyer. Finite Element Analysis of a Ram Brain During Impact Under Wet and Dry Horn Conditions. Journal of Mechanical Behavior of Biomedical Materials. 2021, doi.org/10.1016/j.jmbbm.2021.104400.
Deang, J., Allison, P.G., Prabhu, R., Williams, L.N., Rhee, H., Whittington, W.R., Perkins, E.J., Bruce, S.M., Horstemeyer, M.F. Constitutive behaviour of paddlefish (Polyodon spathula) cartilage. Bioinspired, Biomimetic and Nanobiomaterials. 2017, DOI: 10.1680/jbibn.16.00046
[DOI]Lee, N., Williams, L. N., Mun, S., Rhee, H., Prabhu, R; Bhattarai, K., Horstemeyer, M. “Stress wave mitigation at suture interfaces. Biomedical Physics and Engineering Express.” 2017, DOI: 10.1088/2057-1976/aa777e
[DOI]Lee, Nayeon, Horstemeyer, M.F, Prabhu, R., Liao, J., Rhee, H., Hammi, Y., Moser, Robert D., Williams, L.N The geometric effects of a woodpecker’s hyoid apparatus for stress wave mitigation. Bioinspiration & Biomimetics. 11, 2016, DOI:10.1088/1748-3190/11/6/066004
[PDF] [DOI]Lee, N., Horstemeyer, M., Rhee, H. Nabors, B., Liao, J., Williams, L.N. Hierarchical Multiscale Structure-Property Relationships of the Red-bellied Woodpecker, Journal of the Royal Society Interface. 11, 2014: 1-12. DOI: 10.1098/rsif.2014.0274
[PDF] [DOI]Johnson, Kyle, Trim, W.M., Horstemeyer, M.F., Lee, N., Williams, L.N., Liao, J., Rhee, H., Prabhu, R., Geometric Effects on Stress Wave Propagation, Journal of Biomechanical Engineering. 12, 2013: DOI:10.1115/1.402632
[PDF] [DOI]Trim, M.W., Horstemeyer, M.F., Rhee, H., Liao, J., Williams, L.N. The effects of water and microstructure on the mechanical properties of bighorn sheep (Ovis canadensis) horn keratin, Acta Biomaterialia. 7(3), 2011:1228-1240
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Repetitive Traumatic Brain Injury (TBI)
We are using novel imaging techniques in pre-clinical mild TBI models in an effort to accurately quantify mechanistic changes in the brain associated with repetitive blunt and blast brain trauma.
Effect of Traumatic Brain Injury (TBI) on Perivascular Spaces (PVS)
TM3 is studying the effect of mild traumatic brain injuries (TBI) on the perivascular spaces (PVS) in the brain and their subsequent effect on waste clearance. There have been studies conducted independently that study the adverse effects of TBI on PVS as well as PVS being directly implicated in waste clearance of molecules such as Amyloid-Beta or other neurodegenerative-inducing molecules. This study seeks to combine prior research into a novel study that begins to reveal the detrimental effects of TBI on the human brain.