Murphy, M.A., Mun, Sungkwang, Horstemeyer, M.F., MI Baskes, M.I., Bakhtiary,A., LaPlaca, Michelle C., Gwaltney, Steven R., Williams, L.N., Prabhu, R.K. Molecular dynamics simulations showing 1-palmitoyl-2-oleoyl-phosphatidylcholine (POPC) membrane mechanoporation damage under different strain paths, Journal of Biomolecular Structures and Dynamics. 2019, 37. PMID: 29629830
[DOI]Rush, G. Alston, Prabhu, R., Rush, Gus A. III, Williams, L.N., Horstemeyer, M.F., A Modified Drop Test for American Football Helmets, Journal of Visualized Experiments, 2017, 120. PMID: 28287543
[DOI]Prabhu, R., Whittington, Wilburn., Jones, Michael David, Darwall, Dan, Liao, Jun, Williams, L.N. Dynamic compressive mechanical properties of the porcine immature brain. Brain Injury. 2016, 30. https://www.tandfonline.com/doi/full/10.3109/02699052.2016.1162060
Murphy, M.A., Horstemeyer, M.F., Gwaltney, S., Stone, T., Laplaca, Michelle, Liao, J., Williams, L.N., Prabhu, R. Nanomechanics of phospholipid bilayer failure under strip biaxial stretching using molecular dynamics. Modelling and Simulation in Materials Science and Engineering. 2016, 24. https://iopscience.iop.org/article/10.1088/0965-0393/24/5/055008
Begonia, M.T., Prabhu, R., Liao, J., Whittington, W.R., Claude, A., Willeford, B., Wardlaw, J., Wu, R., Zhang, S., Williams, L.N. Quantitative Analysis of Brain Microstructure Following Blunt and Blast Trauma, Journal of Biomechanics. 2014, 47. PMID: 25446270
[PDF]Prabhu, R., Horstemeyer, M., Marin, E., Bouvard, J-L., Tucker, M., Sherburn, J., Liao, J., Williams, L.N., Coupled Experiment / Finite Element Analysis on the Mechanical Response of Porcine Brain under High Strain Rates, Journal of Mechanical Behavior of Biological Materials. 2011, 4. PMID: 26067742
[PDF]Begonia, M., Liao, J., Horstemeyer, M., Williams, L.N., Structure-Property Relations of Porcine Brain Tissue: Strain Rate and Stress-State Dependence, Annals of Biomedical Engineering. 38(10), 2010:3043-57
[PDF]
TM3 is investigating the deformation behavior of native cranial soft tissues to lay a scientific foundation for designing superior tissue surrogates with optimized properties, and developing a tissue engineered dura mater patch with the objective of preventing problems associated with synthetic patches which include CSF leakage and patch integration with the native tissue.
TM3 is developing a constitutive model of the anterior cruciate ligament in an effort to model mechanistic changes that cannot be captured experimentally.
Knapp, Alexander M., and Williams, L.N. A Computational Investigation of Microstructural Damage of the ACL Under High Loading of the Knee Joint. Journal of Biomechanics Engineering, 2022, 145. PMID: 35900855
Achinger, K. and Williams, L.N. Trends in CSF leakage associated with duraplasty in infratentorial procedures over the last twenty years: A Systematic Review, Critical Reviews in Biomedical Engineering. 2023, 51. PMID: 37551907
Sharma, A., Liao, J., and Williams, L.N. Structure and mechanics of native and decellularized porcine cranial dura mater, Engineered Regeneration. 2023, 4. https://www.sciencedirect.com/science/article/pii/S2666138123000154.
Sharma, A. , Moore, Erika, and Williams, L.N. An in vitro study of micromechanics, cellular proliferation and viability on both decellularized porcine dura grafts and native porcine dura grafts, Biomedical Engineering Advances. 2023, 6. PMID: 38259430
Knapp, Alexander M., and Williams, L. N. Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, Bioengineering. 2022, 9. PMID: 35200406
Begonia, Mark T., Knapp, Alexander M., Prabhu, R.K., Liao, J., Williams, L.N., Shear-deformation based continuum-damage constitutive modeling of brain tissue, Journal of Biomechanics. 2021, 117. PMID: 33515903
Brazile, Bryn L., Butler, J. Ryan, Patnaik, Sourav S., Claude, Andrew, Prabhu, Raj, Williams, L.N., Perez, Karla, L., Nguyen, Kytai T., Zhang, Ge, Bajona, Pietro, Peltz , Matthias, Yang, Yong C., Hong, Yi , Liao, Jun. Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction, Journal of Mechanical Behavior of Biomedical Materials. 2021, 116. PMID: 33516128
Prabhu, R.K, Begonia, M.T., Whittington, W.R., Murphy, M.A., Mao, Y., Liao, J., Williams, L.N. , Horstemeyer M.F., Sheng, J. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects, Bioengineering. 2019, 40. PMID: 31067801
[DOI]Chen, Joseph, Patnaik, Sourav S., Prabhu, R. K., Priddy, Lauren, P., Bouvard, Jean-Luc, Marin, Esteban, Horstemeyer, M.F., Liao, J., Williams, L.N. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression, Bioengineering. 2019, 49. PMID: 31151177
[DOI]Chen, J., Bryn, B. Prabhu, R., Patnaik, S.S., Bertucci, R., Rhee, H., Horstemeyer, M.F., Hong, Y., Williams, L. N., Liao, J. Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear, Journal of Biomechanical Engineering. 2018, 140. PMID: 29715364
[PDF] [DOI]Prabhu, R., Kovach, A. D., Nguyen, V., Gambino, J., Zachary, F., Bulla, S., Liao, J., Williams, L.N. Prospective preliminary in vitro investigation of a magnetic iron oxide nanoparticle conjugated with ligand CD80 and VEGF antibody as a targeted drug delivery system for the induction of cell death in rodent osteosarcoma cells. Bioresearch Open Access. 2016, 5. PMID: 27843708
Prabhu, R., Horstemeyer, M., Mao, M., Whittington, W., Patnaik, S., Begonia, M., Williams, L.N., Liao, J. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials, Journal of Visualized Experiments. 2015, 18. PMID: 26067742
Li, F., Yang, J., Liao, Jiali, Li, S., Liao, Jun, Prabhu, R., Williams, L.N., Tang, Y., Tang, J., Liu, N. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 2015, 276. https://www.sciencedirect.com/science/article/pii/S1385894715005811
Weed, B., Patnaik, S., Rougeau-Browning, M., Brazile, B., Liao, J., Prabhu, R., Williams, L.N. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 2015, 8. https://www.mdpi.com/1996-1944/8/5/2454
Wheatley, B. B., Pietsch, R. B., Donahue, T.L.H., Williams, L.N. Fully non-linear hyper-viscoelastic modeling of skeletal muscle in compression. Computer Methods in Biomechanics and Biomedical Engineering. 2015, 19. PMID: 26652761
[DOI]Brazile, B., Wang, B., Wang, G., Bertucci, R., Prabhu, R., Patnaik, S.S., Butler, J.R. , Claude, A.K.,Brinkman-Ferguson, E., Williams, L.N., Liao, J. . On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants 2015, 25. PMID: 25955006
Pietsch, R., Wheatley, B.B., Donahue, T.L.H., Gilbrech, R., Prabhu, R., Liao, J., Williams, L.N. Anisotropic Compressive Properties of Passive Porcine Muscle Tissue, Journal of Biomechanical Engineering. 2014, 136. PMID: 25068816
[DOI]Wang, B., Wang, G., To, F., Butler, J.R., Claude, A., McLaughlin, R.M., Williams, L. N., de Jongh Curry, A.L., Liao, J. . Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations. Langmuir. 2013, 29. PMID: 23923967
Weed B.C., Borazjani, A., Patnaik, S.S., Prabhu, R., Horstemeyer, M.F., Ryan, P.L., Franz, T., Williams, L. N., Liao, J. Stress State and Strain Rate Dependence of the Human Placenta, Annals of Biomedical Engineering. 2012, 40. PMID: 22581478
Wang, B., Tedder, M.E., Perez, C.E., Wang, G., Curry, A.L., To, F., Elder, S. H., Williams, L. N., Simionescu, D. T., Liao, J. Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix, Journal of Materials Science: Materials in Medicine. 2012, 23. PMID: 22584822
[PDF]Bertucci, R., Gilbrech, R., Mao, M., Prabhu, R., Horstemeyer, M.F., Liao, J., Williams, L.N. Development of a Lower Extremity Model at Blast Conditions HFM-207, North Atlantic Treaty Organization (NATO) Symposium on Blast Injury. No. 17, 2011. Undisclosed Department of Defense Publication.
Liao, J., Joyce, E.M., Merryman, D.W., Jones, H.L., Tahai, M., Horstemeyer, M.F., Williams, L.N., Hopkins, R.A., Sacks, M.S. The Intrinsic Fatigue Mechanism of the Porcine Aortic Valve Extracellular Matrix, Cardiovascular Engineering and Technology. 2012, 3. https://link.springer.com/article/10.1007/s13239-011-0080-4
[PDF]Clemmer, J., Liao, J., Davis, D., Horstemeyer, M., Williams, L.N., A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon, Journal of Biomechanics. 2010, 43. PMID: 20678772
Subramanian, S., Elder, S. H., Horstemeyer, M.F., Williams, L.N. Experimental Investigations of Anisotropic Shear Properties of Rabbit Patellar Tendon, Biological Engineering. 2008, 1. https://elibrary.asabe.org/abstract.asp?aid=25334
Williams, L.N., Elder, S. H., Bouvard, J.L., Horstemeyer, M.F., The Anisotropic Compressive Mechanical Properties of the Rabbit Patellar Tendon, Biorheology. 2008,45. PMID: 19065006
Williams, L.N., Elder, S.H., Harbarger, D., Horstemeyer, M.F., Variation of diameter distribution, number density, and area fraction of fibrils within five areas of the Rabbit Patellar Tendon, Annals of Anatomy. 2008, 19. PMID: 18710799
[PDF]Claude, L.N., Solomonow, M., Zhou, B., Baratta R.V., Zhu, M. Neuromuscular Disorder Elicited by Cyclic Lumbar Flexion. Muscle and Nerve. 2003, 27. PMID: 12635122
Knapp, Alexander M., and Williams, L.N. A Computational Investigation of Microstructural Damage of the ACL Under High Loading of the Knee Joint. Journal of Biomechanics Engineering, 2022, 145. PMID: 35900855
Achinger, K. and Williams, L.N. Trends in CSF leakage associated with duraplasty in infratentorial procedures over the last twenty years: A Systematic Review, Critical Reviews in Biomedical Engineering. 2023, 51. PMID: 37551907
Sharma, A., Liao, J., and Williams, L.N. Structure and mechanics of native and decellularized porcine cranial dura mater, Engineered Regeneration. 2023, 4. https://www.sciencedirect.com/science/article/pii/S2666138123000154.
Sharma, A. , Moore, Erika, and Williams, L.N. An in vitro study of micromechanics, cellular proliferation and viability on both decellularized porcine dura grafts and native porcine dura grafts, Biomedical Engineering Advances. 2023, 6. PMID: 38259430
Knapp, Alexander M., and Williams, L. N. Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, Bioengineering. 2022, 9. PMID: 35200406
Begonia, Mark T., Knapp, Alexander M., Prabhu, R.K., Liao, J., Williams, L.N., Shear-deformation based continuum-damage constitutive modeling of brain tissue, Journal of Biomechanics. 2021, 117. PMID: 33515903
Brazile, Bryn L., Butler, J. Ryan, Patnaik, Sourav S., Claude, Andrew, Prabhu, Raj, Williams, L.N., Perez, Karla, L., Nguyen, Kytai T., Zhang, Ge, Bajona, Pietro, Peltz , Matthias, Yang, Yong C., Hong, Yi , Liao, Jun. Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction, Journal of Mechanical Behavior of Biomedical Materials. 2021, 116. PMID: 33516128
Prabhu, R.K, Begonia, M.T., Whittington, W.R., Murphy, M.A., Mao, Y., Liao, J., Williams, L.N. , Horstemeyer M.F., Sheng, J. Compressive Mechanical Properties of Porcine Brain: Experimentation and Modeling of the Tissue Hydration Effects, Bioengineering. 2019, 40. PMID: 31067801
[DOI]Chen, Joseph, Patnaik, Sourav S., Prabhu, R. K., Priddy, Lauren, P., Bouvard, Jean-Luc, Marin, Esteban, Horstemeyer, M.F., Liao, J., Williams, L.N. Mechanical Response of Porcine Liver Tissue under High Strain Rate Compression, Bioengineering. 2019, 49. PMID: 31151177
[DOI]Chen, J., Bryn, B. Prabhu, R., Patnaik, S.S., Bertucci, R., Rhee, H., Horstemeyer, M.F., Hong, Y., Williams, L. N., Liao, J. Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear, Journal of Biomechanical Engineering. 2018, 140. PMID: 29715364
[PDF] [DOI]Prabhu, R., Kovach, A. D., Nguyen, V., Gambino, J., Zachary, F., Bulla, S., Liao, J., Williams, L.N. Prospective preliminary in vitro investigation of a magnetic iron oxide nanoparticle conjugated with ligand CD80 and VEGF antibody as a targeted drug delivery system for the induction of cell death in rodent osteosarcoma cells. Bioresearch Open Access. 2016, 5. PMID: 27843708
Prabhu, R., Horstemeyer, M., Mao, M., Whittington, W., Patnaik, S., Begonia, M., Williams, L.N., Liao, J. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials, Journal of Visualized Experiments. 2015, 18. PMID: 26067742
Li, F., Yang, J., Liao, Jiali, Li, S., Liao, Jun, Prabhu, R., Williams, L.N., Tang, Y., Tang, J., Liu, N. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 2015, 276. https://www.sciencedirect.com/science/article/pii/S1385894715005811
Weed, B., Patnaik, S., Rougeau-Browning, M., Brazile, B., Liao, J., Prabhu, R., Williams, L.N. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 2015, 8. https://www.mdpi.com/1996-1944/8/5/2454
Wheatley, B. B., Pietsch, R. B., Donahue, T.L.H., Williams, L.N. Fully non-linear hyper-viscoelastic modeling of skeletal muscle in compression. Computer Methods in Biomechanics and Biomedical Engineering. 2015, 19. PMID: 26652761
[DOI]Brazile, B., Wang, B., Wang, G., Bertucci, R., Prabhu, R., Patnaik, S.S., Butler, J.R. , Claude, A.K.,Brinkman-Ferguson, E., Williams, L.N., Liao, J. . On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants 2015, 25. PMID: 25955006
Pietsch, R., Wheatley, B.B., Donahue, T.L.H., Gilbrech, R., Prabhu, R., Liao, J., Williams, L.N. Anisotropic Compressive Properties of Passive Porcine Muscle Tissue, Journal of Biomechanical Engineering. 2014, 136. PMID: 25068816
[DOI]Wang, B., Wang, G., To, F., Butler, J.R., Claude, A., McLaughlin, R.M., Williams, L. N., de Jongh Curry, A.L., Liao, J. . Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations. Langmuir. 2013, 29. PMID: 23923967
Weed B.C., Borazjani, A., Patnaik, S.S., Prabhu, R., Horstemeyer, M.F., Ryan, P.L., Franz, T., Williams, L. N., Liao, J. Stress State and Strain Rate Dependence of the Human Placenta, Annals of Biomedical Engineering. 2012, 40. PMID: 22581478
Wang, B., Tedder, M.E., Perez, C.E., Wang, G., Curry, A.L., To, F., Elder, S. H., Williams, L. N., Simionescu, D. T., Liao, J. Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix, Journal of Materials Science: Materials in Medicine. 2012, 23. PMID: 22584822
[PDF]Bertucci, R., Gilbrech, R., Mao, M., Prabhu, R., Horstemeyer, M.F., Liao, J., Williams, L.N. Development of a Lower Extremity Model at Blast Conditions HFM-207, North Atlantic Treaty Organization (NATO) Symposium on Blast Injury. No. 17, 2011. Undisclosed Department of Defense Publication.
Liao, J., Joyce, E.M., Merryman, D.W., Jones, H.L., Tahai, M., Horstemeyer, M.F., Williams, L.N., Hopkins, R.A., Sacks, M.S. The Intrinsic Fatigue Mechanism of the Porcine Aortic Valve Extracellular Matrix, Cardiovascular Engineering and Technology. 2012, 3. https://link.springer.com/article/10.1007/s13239-011-0080-4
[PDF]Clemmer, J., Liao, J., Davis, D., Horstemeyer, M., Williams, L.N., A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon, Journal of Biomechanics. 2010, 43. PMID: 20678772
Subramanian, S., Elder, S. H., Horstemeyer, M.F., Williams, L.N. Experimental Investigations of Anisotropic Shear Properties of Rabbit Patellar Tendon, Biological Engineering. 2008, 1. https://elibrary.asabe.org/abstract.asp?aid=25334
Williams, L.N., Elder, S. H., Bouvard, J.L., Horstemeyer, M.F., The Anisotropic Compressive Mechanical Properties of the Rabbit Patellar Tendon, Biorheology. 2008,45. PMID: 19065006
Williams, L.N., Elder, S.H., Harbarger, D., Horstemeyer, M.F., Variation of diameter distribution, number density, and area fraction of fibrils within five areas of the Rabbit Patellar Tendon, Annals of Anatomy. 2008, 19. PMID: 18710799
[PDF]Claude, L.N., Solomonow, M., Zhou, B., Baratta R.V., Zhu, M. Neuromuscular Disorder Elicited by Cyclic Lumbar Flexion. Muscle and Nerve. 2003, 27. PMID: 12635122
TM3 lab generates 3D reconstructions of tissues and organs from CT and MR images. Finite element models of these reconstructions are created to predict injury to the tissues and organs while subjected to various conditions.
TM3 lab is working on designing impact mitigating materials inspired from natural systems. We are using lessons from nature to optimize designs of protective gear for soldiers and athletes.
Knapp, Alexander M., and Williams, L.N. A Computational Investigation of Microstructural Damage of the ACL Under High Loading of the Knee Joint. Journal of Biomechanics Engineering, 2022, 145. PMID: 35900855
Knapp, Alexander M., and Williams, L. N. Predicting the Effect of Localized ACL Damage on Neighbor Ligament Mechanics via Finite Element Modeling, Bioengineering. 2022, 9. PMID: 35200406
Johnson, K.L., Trim, M.W., Mao, Y., Rhee, H., Williams, L.N., Liao, J., Griggs, J., Horstemeyer, M.F. Finite Element Analysis of a Ram Brain During Impact Under Wet and Dry Horn Conditions. Journal of Mechanical Behavior of Biomedical Materials. 2021, 119. PMID: 33893020
Deang, J., Allison, P.G., Prabhu, R., Williams, L.N., Rhee, H., Whittington, W.R., Perkins, E.J., Bruce, S.M., Horstemeyer, M.F. Constitutive behaviour of paddlefish (Polyodon spathula) cartilage. Bioinspired, Biomimetic and Nanobiomaterials. 2017, 6. https://www.icevirtuallibrary.com/doi/10.1680/jbibn.16.00046
[DOI]Lee, N., Williams, L. N., Mun, S., Rhee, H., Prabhu, R; Bhattarai, K., Horstemeyer, M. Stress wave mitigation at suture interfaces. Biomedical Physics and Engineering Express. 2017, 3. https://iopscience.iop.org/article/10.1088/2057-1976/aa777e
Lee, Nayeon, Horstemeyer, M.F, Prabhu, R., Liao, J., Rhee, H., Hammi, Y., Moser, Robert D., Williams, L.N. The geometric effects of a woodpecker’s hyoid apparatus for stress wave mitigation. Bioinspiration & Biomimetics. 2016, 11. PMID: 27780157
[PDF] [DOI]Lee, N., Horstemeyer, M., Rhee, H. Nabors, B., Liao, J., Williams, L.N. Hierarchical Multiscale Structure-Property Relationships of the Red-bellied Woodpecker, Journal of the Royal Society Interface. 2014, 11 PMID: 24812053
[PDF] [DOI]Johnson, K.L., Trim,M.W., Horstemeyer, M.F., Lee, N., Williams, L.N., Liao, J., Rhee, H., Prabhu, R., Geometric Effects on Stress Wave Propagation, Journal of Biomechanical Engineering. 2013, 12. PMID: 24362893
Trim, M.W., Horstemeyer, M.F., Rhee, H., Liao, J., Williams, L.N. The effects of water and microstructure on the mechanical properties of bighorn sheep (Ovis canadensis) horn keratin, Acta Biomaterialia. 2011, 7. PMID: 21095245
[PDF]
Repetitive Traumatic Brain Injury (TBI)
We are using novel imaging techniques in pre-clinical mild TBI models in an effort to accurately quantify mechanistic changes in the brain associated with repetitive blunt and blast brain trauma.
Effect of Traumatic Brain Injury (TBI) on Perivascular Spaces (PVS)
TM3 is studying the effect of mild traumatic brain injuries (TBI) on the perivascular spaces (PVS) in the brain and their subsequent effect on waste clearance. There have been studies conducted independently that study the adverse effects of TBI on PVS as well as PVS being directly implicated in waste clearance of molecules such as Amyloid-Beta or other neurodegenerative-inducing molecules. This study seeks to combine prior research into a novel study that begins to reveal the detrimental effects of TBI on the human brain.